Pyrintegrin
货号：
16179-1mg 基本售价：
910.0 元 规格：
1 mg
产品信息
概述| 货号 | 16179-1mg |
| 描述 | Human embryonic stem cells (hESC), unlike murine ESC, grow in vitro as large flattened two dimensional colonies.1 Dispersing these colonies, using trypsin to dissociate single hESC, results in massive cell death.1 Pyrintegrin is a 2,4-disubstituted pyrimidine that, at 2 µM, enhances the survival of hESC more than 30-fold after trypsin-mediated dissociation.1 It increases integrin-dependent attachment of hESC to extracellular matrices, including Matrigel™ and laminin, without significantly impacting cell proliferation.1 Pyrintegrin increases the binding of the activated β1 integrin-specific antibody HUTS-21 and enhances the phosphorylation of multiple growth factor receptors and their downstream kinases, PI3K and MAPK.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Xu, Y.,Zhu, X.,Hahm, H.S., et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proceedings of the National Academy of Sciences of the United States of America 107(18), 8129-8134 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 451.5 |
| 分子式 | C23H25N5O3S |
| CAS号 | 1228445-38-2 |
| 稳定性 | ≥ 2 years |
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