| 货号 | 15014-10mg |
| 描述 | Miglitol is a pseudo-carbohydrate which inhibits α-glucosidases, inhibiting lysosomal α-glucosidase, sucrase, maltase, and isomaltase (IC50s = 0.35, 0.11, 1.3, and 1.2 μM, respectively).1,2 It also inhibits maltase-glucoamylase (IC50 = 1.0 μM).3 Miglitol can be used to prevent postprandial hyperglycemia associated with diabetes without cardiovascular complications.4 |
| 别名 | BAY-1099;Diastabol;Glyset;Seibule; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kuriyama, C.,Kamiyama, O.,Ikeda, K., et al. In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorganic & Medicinal Chemistry 16(15), 7330-7336 (2008). 2.Natori, Y.,Imahori, T.,Murakami, K., et al. The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors. Bioorganic & Medicinal Chemistry Letters 21(2), 738-741 (2011). 3.Mohan, S.,Sim, L.,Rose, D.R., et al. Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative. Bioorganic & Medicinal Chemistry 18(22), 7794-7798 (2010). 4.Standl, E. and Schnell, O. Alpha-glucosidase inhibitors 2012 - cardiovascular considerations and trial evaluation. Diab.Vasc.Dis.Res. 9(3), 163-169 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 207.2 |
| 分子式 | C8H17NO5 |
| CAS号 | 72432-03-2 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |