| 货号 | 14484-250mg |
| 描述 | Buthionine sulfoximine (BSO) is an irreversible inhibitor of γ-glutamylcysteine synthetase (Ki<100 μM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH.1,2 Administration of BSO leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis.3,4 Whereas elevated glutathione levels are associated with tumor cell resistance, BSO has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors.5 |
| 别名 | BSO;L-Buthionine-S,R-Sulfoximine;NSC 326231; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Reliene, R. and Schiestl, R.H. Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. Carcinogenesis 27(2), 240-244 (2006). 2.Griffith, O.W. Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J.Biol.Chem 257(22), 13704-13712 (1982). 3.Takahashi, K.,Tatsunami, R.,Oba, T., et al. Buthionine sulfoximine promotes methylglyoxal-induced apoptotic cell death and oxidative stress in endothelial cells. Biological and Pharmaceutical Bullentin 33(4), 556-560 (2010). 4.Han, Y.H.,Moon, H.J.,You, B.R., et al. The effects of buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on propyl gallate-treated HeLa cells in relation to cell growth, reactive oxygen species and glutathione. International Journal of Molecular Medicine 24(2), 261-268 (2009). 5.Lewis-Wambi, J.S.,Kim, H.R.,Wambi, C., et al. Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis. Breast Cancer Research 10(6), (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 222.3 |
| 分子式 | C8H18N2O3S |
| CAS号 | 83730-53-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |