| 货号 | 14465-1mg |
| 描述 | Ac-DEVD-CMK is a cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10.1,2,3 It is commonly used at concentrations up to 100 μM to examine the role of caspase-3-dependent apoptosis in biological systems.4,1 |
| 别名 | Ac-Asp-Glu-Val-Asp-CMK;Caspase-3 Inhibitor III; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mocanu, M.M.,Baxter, G.F. and Yellon, D.M. Caspase inhibition and limitation of myocardial infarct size: Protection against lethal reperfusion injury. British Journal of Pharmacology 130(2), 197-200 (2000). 2.Schrantz, N.,Blanchard, D.A.,Mitenne, F., et al. Manganese induces apoptosis of human B cells: Caspase-dependent cell death blocked by Bcl-2. Cell Death and Differentiation 6(5), 445-453 (1999). 3.Thornberry, N.A. and Lazebnik, Y. Caspases: Enemies within. Science 281, 1312-1316 (1998). 4.Zhang, Y.,Wang, H.,Li, J., et al. Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. Journal of Neuroscience 24(47), 10616-10627 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 551 |
| 分子式 | C21H31ClN4O11 |
| CAS号 | 285570-60-7 |
| 稳定性 | ≥ 2 years |
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