| 货号 | 14462-1mg |
| 描述 | Z-FA-FMK is an irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain.1 It also inhibits effector caspases-2, -3, -6, and -7 (IC50 = 6-32 µM) without affecting the initiator caspases-8 and -10.2 Z-FA-FMK also modulates infection by certain bacteria, parasites, and viruses.3,4,5 It can be used both in cells and in vivo.4,5 |
| 别名 | Z-Phe-Ala-Fluoromethyl Ketone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ahmed, N.K.,Martin, L.A.,Watts, L.M., et al. Peptidyl fluoromethyl ketones as inhibitors of cathepsin B. Implication for treatment of rheumatoid arthritis. Biochemical Pharmacology 44, 1201-1207 (1992). 2.Lopez-Hernandez, F.J.,Ortiz, M.A.,Bayon, Y., et al. Z-FA-fmk inhibits effector caspases but not initiator caspases 8 and 10, and demonstrates that novel anticancer retinoid-related molecules induce apoptosis via the intrinsic pathway. Molecular Cancer Therapeutics 2(3), 255-263 (2003). 3.Harth, G.,Andrews, N.,Mills, A.A., et al. Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi. Molecular and Biochemical Parasitology 58, 17-24 (1993). 4.Lawrence, C.P.,Kadioglu, A.,Yang, A.L., et al. The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo. Journal of Immunology 177, 3827-3836 (2006). 5.Kim, M.,Hansen, K.K.,Davis, L., et al. Z-FA-FMK as a novel potent inhibitor of reovirus pathogenesis and oncolysis in vivo. Antivir.Ther. 15(6), 897-905 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 386.4 |
| 分子式 | C21H23FN2O4 |
| CAS号 | 197855-65-5 |
| 稳定性 | ≥ 2 years |
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