MK2 Inhibitor IV
货号：
14399-5mg 基本售价：
910.0 元 规格：
5 mg
产品信息
概述| 货号 | 14399-5mg |
| 描述 | Activation of the p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2) pathway has been implicated in promoting pro-inflammatory cytokine production and related inflammatory diseases. MK2 Inhibitor IV is a highly selective, non-ATP competitive MK2 inhibitor with an IC50 value of 0.11 μM.1 MK2 Inhibitor IV has been shown to inhibit pro-inflammatory cytokine secretion from the human THP-1 acute monocytic leukemia cell line, causing inhibition of LPS-stimulated TNF-α (IC50 = 4.4 μM) and IL-6 (IC50 = 5.2 μM) secretion.1 It can also inhibit IL-1β-stimulated matrixmetalloprotease 13 secretion from the SW1353 chondrosarcoma cell line (IC50 = 5.7 μM) and human primary chondrocyte cultures (IC50 = 2.2 μM).1 |
| 别名 | MK 25; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Huang, X.,Shipps, G.W., Jr.,Cheng, C.C., et al. Discovery and hit-to-lead optimization of non-ATP competitive MK2 (MAPKAPK2) inhibitors. ACS Med.Chem.Lett. 2, 632-637 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 509.4 |
| 分子式 | C27H25ClN4O2 • HCl |
| CAS号 | 1314118-94-9 |
| 稳定性 | ≥ 2 years |
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