Prolyl-glycyl-proline Peptide
货号：
11188-5mg 基本售价：
910.0 元 规格：
5 mg
产品信息
概述| 货号 | 11188-5mg |
| 描述 | Proline-glycine-proline (PGP) is a tripeptide molecule and an established biomarker for chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF).1 PGP functions as a neutrophil chemoattractant and is derived from the proteolytic cleavage of collagen in the extracellular matrix by a multistep cascade. First, the matrix metalloproteases MMP-8 or MMP-9 cleave collagen to peptides 30-100 amino acids in length. Prolyl endopeptidase further cleaves the collagen fragments to PGP. PGP and the related peptide N-acetylated PGP (Item No. 11189) act through chemokine receptors CXCR1 and CXCR2 on neutrophil cells.2 Patients with cystic fibrosis have been shown to have elevated levels of PGP peptides in sputum.1 PGP, but not N-acetylated PGP, has been demonstrated to be a substrate for the pro-inflammatory enzyme LTA4hydrolase.3 |
| 别名 | PGP; |
性能| 供应商 | Cayman |
| 应用文献 |
1.OReilly, P.,Jackson, P.L.,Noerager, B., et al. N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD. Respiratory Research 10, 1-8 (2009).
2.Weathington, N.M.,van Houwelingen, A.H.,Noerager, B.D., et al. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nature Medicine 12(3), 317-323 (2006).
3.Snelgrove, R.J.,Jackson, P.L.,Hardison, M.T., et al. A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation. Science 330, 90-94 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% by HPLC |
| 计算分子量 | 269.3 |
| 稳定性 | ≥ 1 year |
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