| 货号 | 10010268-1mg |
| 描述 | Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate.1,2 It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 µM).2 It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.3,4,5 |
| 别名 | NSC 678027;RG-14355; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Onoda, T.,Iinuma, H.,Sasaki, Y., et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. Journal of Natural Products 52(6), 1252-1257 (1989). 2.Hsu, C.-Y.J.,Persons, P.E.,Spada, A.P., et al. Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by lavendustin-A and its analogue. J. Biol. Chem. 266(31), 21105-21112 (1991). 3.Hwang, K.C.,Kim, J.Y.,Chang, W., et al. Chemicals that modulate stem cell differentiation. Proceedings of the National Academy of Sciences of the United States of America 105(21), 7467-7471 (2008). 4.ODell, T.J.,Kandel, E.R., and Grant, S.G.N. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353, 558-560 (1991). 5.Fan, T.P.D.,Jaggar, R., and Bicknell, R. Controlling the vasculature: Angiogenesis, anti-angiogenesis and vascular targeting of gene therapy. Trends in Pharamacological Sciences 16(2), 57-66 (1995). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 381.4 |
| 分子式 | C21H19NO6 |
| CAS号 | 125697-92-9 |
| 稳定性 | ≥ 2 years |
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