| 货号 | 5981/50 |
| 别名 | 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl) |
| 供应商 | Tocris |
| 生物活性 | SMO antagonist (IC50 = 690 nM); acts at different binding site to cyclopamine (Cat. No. 1623). Also cytochrome p450 inhibitor (IC50 = 16-26 nM). Inhibits cell cycle at G1phasein vitro and blocks angiogenesis in vivo(IC50 = 160 nM). Antifungal. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 705.63 |
| 分子式 | C35H38Cl2N8< |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO with gentle warming |
| 参考文献 | Paceet al (2016) Repurposing the clinically efficacious antifungal agent itraconazole as an anticancer chemotherapeutic. J.Med.Chem. 59 3635. PMID: 27014922. Kimet al (2013) Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell 23 23. PMID: 23291299. Kimet al (2010) Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 17 388. PMID: 20385363. Chonget al (2007) Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem.Biol. 2 263. PMID: 17432820. |