| 货号 | 3619/50 |
| 别名 | 3-Amino-1-propanesulfonic acid; Homotaurine |
| 供应商 | Tocris |
| 生物活性 | Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β(Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 139.17 |
| 分子式 | C3H9NO3S |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 3687-18-1 |
| 参考文献 | Gervaiset al (2007) Targeting soluble Aβ peptide with tramiprosate for the treatment of brain amyloidosis. Neurobiol.Aging 28 537. PMID: 16675063. Santa-Mariaet al (2007) Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Mol.Neurodegen. 217. Farielloet al (1982) Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology 32 241. PMID: 7199633. |