| 货号 | 3948/50 |
| 别名 | α-[4-(1,1-Dimethylethyl)phenyl]-4-(h |
| 供应商 | Tocris |
| 生物活性 | Histamine H1 receptor antagonist. Also blocks KV11.1 (hERG) and Kir6 (KATP) channels (IC50 values are 204 nM and 1.2 μM respectively). Inhibits the delayed rectifier K+ current (IKr) in guinea pig ventricular myocytes (IC50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 471.67 |
| 分子式 | C32H41NO2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| CAS号 | 50679-08-8 |
| 参考文献 | Storket al (2007) State dependent dissociation of HERG channel inhibitors. Br.J.Pharmacol. 151136. Crumb (2000) Loratadine blockade of K+ channels in human heart: comparison with terfenadine under physiological conditions. J.Pharmacol.Exp.Ther. 292 261. PMID: 10604956. Zunkleret al (2000) Mechanism of terfenadine block of ATP-sensitive K+ channels. Br.J.Pharmacol. 130 1571. PMID: 10928959. |