| 货号 | 1478/50 |
| 别名 | 4-(Benzoylamino)-5-(dipropylamino)- |
| 供应商 | Tocris |
| 生物活性 | Non-selective cholecystokinin (CCK) antagonist. Inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 356.39 |
| 分子式 | C18H25N2NaO4 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| 参考文献 | Mausset al (1994) Effects of gastrin, proglumide, loxiglumide and L-365,260 on growth of human colon carcinoma cells. Anticancer Res. 14 215. PMID: 8166452. Iwamotoet al (1984) In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini. Gastroenterol.Jpn. 19 53. PMID: 6202584. Hahneet al (1981) Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists. Proc.Natl.Acad.Sci.U.S.A. 78 6304. PMID: 6171817. |