| 货号 | 3540/10 |
| 别名 | N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-ox |
| 供应商 | Tocris |
| 生物活性 | Hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A2, liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G1/S boundary in vitro. Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 495.73 |
| 分子式 | C29H53NO5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 96829-58-2 |
| 参考文献 | Encet al (2008) Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects. Am.J.Physiol.Gastrointest.Liver Physiol. 296 G482. PMID: 19109408. Kridelet al (2004) Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res. 64 2070. PMID: 15026345. Hadvaryet al (1991) The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase. J.Biol.Chem. 266 2021. PMID: 1899234. |