| 货号 | 4653/50 |
| 别名 | 2-Acetylphenothiazine |
| 供应商 | Tocris |
| 生物活性 | NADPH oxidase 1 (NOX1) inhibitor; blocks NOX1-dependent ROS generation (IC50 = 0.25 μM in a HEK293-NOX1 recombinant cell system). Selective for NOX1 over other NADPH oxidases (IC50 values are > 3 μM). Inhibits SrcYF-induced invadopodia formation in human DLD1 colon cancer cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 241.31 |
| 分子式 | C14H11NOS |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Drummondet al (2011) Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat.Rev.Drug Discov. 10 453. PMID: 21629295. Gianniet al (2010) A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. ACS Chem.Biol. 5 981. PMID: 20715845. |