| 货号 | 4524/50 |
| 别名 | 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2 |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of amyloid assembly; inhibits the formation of amyloid fibrils by proteins such as Aβ,α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits β-secretase (IC50 = 1.6 μM) and glutamate dehydrogenase GDH. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 458.37 |
| 分子式 | C22H18O11 |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 100 mM in ethanol |
| 参考文献 | Sinhaet al (2012) Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. ACS Chem.Neurosci. 3 451. PMID: 22860214. Yanget al (2009) Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res. 69 7986. PMID: 19826036. Shankaret al (2008) EGCG inhibits growth, invasion, angiogenesis and metastastasis of pancreatic cancer. Front.Biosci. 13 440. PMID: 17981559. Leeet al (2005) Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol.Pharmacol. 68 1018. PMID: 16037419. Jeonet al (2003) Green tea catechins as a BACE1 (β-secretase) inhibitor. Bioorg.Med.Chem.Lett. 13 3905. PMID: 14592472. Ahmadet al (2000) Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells. Ach.Biochem.Biophys. 376 338. PMID: 10775421. |