| 货号 | 4523/50 |
| 别名 | 4,4'-Diisothiocyanato-2,2'-stilbenedi |
| 供应商 | Tocris |
| 生物活性 | ClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >95 % |
| 计算分子量 | 498.48 |
| 分子式 | C16H8N2Na2 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO and to 10 mM in Potassium bicarbonate (0.1M) |
| 参考文献 | Zhanget al (2012) Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives. Mol.Pharmacol. 81 689. PMID: 22328719. Ishidaet al (2009) DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange. Nucleic Acids Res. 37 3367. PMID: 19336413. Wulff (2008) New light on the "old" chloride channel blocker DIDS. ACS Chem.Biol. 3 399. PMID: 18642798. Riquelme and Parraet al (1999) Regulation of human placental chloride channel by arachidonic acid and other cis unsaturated fatty acids. Am.J.Obstet.Gynecol. 180 469. PMID: 9988821. |