| 货号 | 4520/50 |
| 别名 | 4-Amino-1-β-D-arabinofuranosyl-2(1H) |
| 供应商 | Tocris |
| 生物活性 | Nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 243.22 |
| 分子式 | C9H13N3O5 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 50 mM in DMSO |
| 参考文献 | Sampathet al (2006) Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. Blood. 107 2517. PMID: 16293603. Breistølet al (1999) Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models. Cancer Res. 59 2944. PMID: 10383159. Yanget al (1986) Effect of cytarabine upon metabolism of phospholipids in leukemia L5178Y cells. Acta Pharmacol. Sin. 7 368. PMID: 2954403. |