| 货号 | 4096/50 |
| 别名 | 1-(2-Chloro-α,α-diphenylbenzyl)imidaz |
| 供应商 | Tocris |
| 生物活性 | Imidazole antimycotic and cytochrome P450 inhibitor. Inhibits Ca2+-activated K+ current (IC50 = 3 μM) and L-type Ca2+ current; increases the firing rate of action potentials. Exhibits antiproliferative activity in vitroandin vivo. Also an inverse agonist of the human constitutive androstane receptor (hCAR). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 344.84 |
| 分子式 | C22H17ClN2 |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 23593-75-1 |
| 参考文献 | Lempiainenet al (2005) Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. Mol.Endocrinol. 19 2258. PMID: 15905360. Thomaset al (1999) The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes. Br.J.Pharmacol. 126 1531. PMID: 10323582. Wuet al (1999) Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells. Neuropharmacology 38 979. PMID: 10428416. Snajdrovaet al (1998) Clomitrazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle. J.Biol.Chem. 273 28032. PMID: 9774419. |