| 货号 | 4095/50 |
| 别名 | 2-Butyl-3-benzofuranyl-4-[2-(diethy |
| 供应商 | Tocris |
| 生物活性 | Broad-spectrum ion channel blocker; blocks late INa, ICa, IKr and IKs and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca2+ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 681.77 |
| 分子式 | C25H29I2NO3.HCl |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| CAS号 | 19774-82-4 |
| 参考文献 | Balgiet al (2009) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4 e7124. PMID: 19771169. Hanet al (2009) Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 4 7155. PMID: 19774075. Antzelevitchet al (2004) Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110 904. PMID: 15302796. di Matolaet al (2000) Amiodarone induces cytochrome c release and apoptosis through an iodine-dependent mechanism. J.Clin.Endocrin.Metab. 85 4323. PMID: 11095475. |