| 货号 | 4999/50 |
| 别名 | 9-Hydroxyphenanthrene |
| 供应商 | Tocris |
| 生物活性 | Selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 194.23 |
| 分子式 | C14H10O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Simardet al (2012) Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle. Br.J.Pharmacol. 165 2354. PMID: 22014185. Grandet al (2008) 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br.J.Pharmacol. 153 1697. PMID: 18297105. |