| 货号 | 3842/50 |
| 别名 | 4-Amino-1-β-D-ribofuranosyl-1,3,5-tr |
| 供应商 | Tocris |
| 生物活性 | DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 244.2 |
| 分子式 | C8H12N4O5 |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 100 mM in DMSO |
| CAS号 | 320-67-2 |
| 参考文献 | Qianet al (2012) 5-Azacytidine induces cardiac differentiation of human umbilical cord-derived mesenchymal stem cells by activating extracellular regulated kinase. Stem Cells Dev. 21 67. PMID: 21476855. Mikkelsenet al (2008) Dissecting direct reprogramming through integrative genomic analysis. Nature 454 49. PMID: 18509334. Schneider-Stocket al (2005) 5-aza-Cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. J.Pharmacol.Exp.Ther. 312 525. PMID: 15547111. |