| 货号 | 4798/10 |
| 别名 | (+)-(S)-N-Methyl-3-(1-naphthyloxy)- |
| 供应商 | Tocris |
| 生物活性 | High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 333.88 |
| 分子式 | C18H19NOS.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO |
| 参考文献 | Kasamoet al (1996) Blockade of the serotonin and norepinephrine uptake processes by duloxetine: in vitro and in vivo studies in the rat brain. J.Pharmacol.Exp.Ther. 277 278. PMID: 8613930. Wonget al (1988) LY227942, an inhibitor of serotonin and norepinephrine uptake: biochemical pharmacology of a potential antidepressant drug. Life Sci. 43 2049. PMID: 2850421. |