| 货号 | 14272-10mg |
| 描述 | Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage.1 Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions.2,3 It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Defeudis, F.V. Bilobalide and neuroprotection. Pharmacological Research 46(6), 565-568 (2002). 2.Kiewert, C.,Kumar, V.,Hildmann, O., et al. Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide. Brain Research 1201, 143-150 (2008). 3.Lang, D.,Kiewert, C.,Mdzinarishvili, A., et al. Neuroprotective effects of bilobalide are accompanied by a reduction of ischemia-induced glutamate release in vivo. Brain Research 1425, 155-163 (2011). 4.Lau, A.J.,Yang, G.,Rajaraman, G., et al. Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor. Drug Metabolism and Disposition 40(1), 178-186 (2012). 5.Deng, Y.,Bi, H.C.,Zhao, L.Z., et al. Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats. Xenobiotica 38(5), 465-481 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 326.3 |
| 分子式 | C15H18O8 |
| CAS号 | 33570-04-6 |
| 稳定性 | ≥ 2 years |
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