| 货号 | 16794-100mg |
| 描述 | Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53 µM, respectively).1 It is commonly synthesized as a racemic mixture of (S) and (R) isomers (Item No. item 70280). (R)-Ibuprofen is an enantiomer that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids.2 The (R) enantiomer can, however, inhibit NF-κB activation (IC50 = 121.8 µM) in response to T-cell stimulation as well as block superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 40-100 µM).3,4 50-60% of (R)-ibuprofen is inverted to (S)-ibuprofen (Item No. 16793) in humans after oral administration.2,5,6 |
| 别名 | (-)-Ibuprofen; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Barnett, J.,Chow, J.,Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochimica et Biophysica Acta 1209, 130-139 (1994). 2.Evans, A.M. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin.Rheumatol. 20, S9-S14 (2001). 3.Scheuren, N.,Bang, H.,Münster, T., et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. British Journal of Pharmacology 123, 645-652 (1998). 4.Villanueva, M.,Heckenberger, R.,Strobach, H., et al. Equipotent inhibition by R(−)-, S(+)- and racemic ibuprofen of human polymorphonuclear cell function in vitro. British Journal of Clinical Pharmacology 35(3), 235-242 (1993). 5.Lee, E.J.D.,Williams, K.,Day, R., et al. Stereoselective disposition of ibuprofen enantiomers in man. British Journal of Clinical Pharmacology 19, 669-674 (1985). 6.Hutt, A.J.,Kooloobandi, A., and Hanlon, G.W. Microbial metabolism of 2-arylpropionic acids: Chiral inversion of ibuprofen and 2-phenylpropionic acid. Chirality 5, 596-601 (1993). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 206.3 |
| 分子式 | C13H18O2 |
| CAS号 | 51146-57-7 |
| 稳定性 | ≥ 2 years |
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