VU590 (hydrochloride)
货号：
15177-5mg 基本售价：
868.0 元 规格：
5 mg
产品信息
概述| 货号 | 15177-5mg |
| 描述 | KCNJ1 (Kir1.1, or renal outer medullary potassium channel) and KCNJ13 (Kir7.1) are inwardly rectifying two-transmembrane K+ channels. KCNJ1 has critical roles in kidney function, while KCNJ13 is important in the eye, kidney, and small intestine.1,2 VU590 is a small molecule inhibitor of KCNJ1 (IC50 = 294 nM) which also causes 70% inhibition of KCNJ13 at 10 µM.3 It has no effect on the related channels KCNJ2 (Kir2.1) and KCNJ10 (Kir4.1) at a concentration of 10 µM.3 |
| 别名 | CID-4536383;ML-111; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hebert, S.C.,Desir, G.,Giebisch, G., et al. Molecular diversity and regulation of renal potassium channels. Physiological Reviews 85(1), 319-371 (2005).
2.Edwards, A.O. Clinical features of the congenital vitreoretinopathies. Eye (Lond) 22(10), 1233-1242 (2008).
3.Denton, J.S.,Weaver, C.D.,Lewis, L.M., et al. Discovery of a small molecule inhibitor of ROMK and Kir7.1. 1-9 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 561.5 |
| 分子式 | C24H32N4O7 • 2HCl |
| 稳定性 | ≥ 2 years |
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