Oxaliplatin
货号：
13106-50mg 基本售价：
868.0 元 规格：
50 mg
产品信息
概述| 货号 | 13106-50mg |
| 描述 | Oxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death.1,2 Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively.2 Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.1,3 |
| 别名 | Dacplat;Eloxatin™;Elplat;Lipoxal;NSC 266046;RP 54780; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Raymond, E.,Chaney, S.G.,Taamma, A., et al. Oxaliplatin: A review of preclinical and clinical studies. Annals of Oncology 9, 1053-1071 (1998).
2.Raymond, E.,Faivre, S.,Chaney, S., et al. Cellular and molecular pharmacology of oxaliplatin. Molecular Cancer Therapeutics 1, 227-235 (2002).
3.Di Leo, A.,Buyse, M., and Bleiberg, H. Is overall survival a realistic primary end point in advanced colorectal cancer studies? A critical assessment based on four clinical trials comparing fluorouracil plus leucovorin with the same treatment combined either with oxaliplatin or with CPT-11. Annals of Oncology 15, 545-549 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 397.3 |
| 分子式 | C8H14N2O4Pt |
| CAS号 | 61825-94-3 |
| 稳定性 | ≥ 2 years |
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