(5Z)-7-Oxo Zeaenol
货号：
17459-1mg 基本售价：
864.0 元 规格：
1 mg
产品信息
概述| 货号 | 17459-1mg |
| 描述 | Transforming growth factor-β-activated kinase 1 (TAK1) is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family that activates JNK/p38 and NF-κB pro-inflammatory signaling pathways. (5Z)-7-Oxo zeaenol is a natural resorcylic lactone derived from fungi that selectively inhibits purified TAK1 (IC50 = 8.1 nM when co-expressed with the TAK1-binding protein) without significantly affecting the kinase activities of other MAPKKK family members (IC50 = 411 nM for MEK1).1 In cells, (5Z)-7-oxo zeaenol is reported to irreversibly block IL-1-induced activation of TAK1, NF-κB, and JNK/p38 with IC50 values of 65-83 nM.1 (5Z)-7-Oxo zeaenol has also been shown to inhibit IL-1-induced COX-2 production in cells and to relieve ear swelling induced by picryl chloride in a mouse model of COX-2-mediated inflammation.1 This compound has been found to sensitize cells to TRAIL- and TNF-α-induced apoptosis in vitro.2 |
| 别名 | FR148083;L-783,279;LL-Z 1640-2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ninomiya-Tsuji, J.,Kajino, T.,Ono, K., et al. A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. The Journal of Biological Chemisty 278(20), 18485-18490 (2003).
2.Choo, M.K.,Kawasaki, N.,Singhirunnusorn, P., et al. Blockade of transforming growth factorβactivated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade. Molecular Cancer Therapeutics 5(12), 2970-2976 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 362.4 |
| 分子式 | C19H22O7 |
| CAS号 | 253863-19-3 |
| 稳定性 | ≥ 2 years |
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