| 货号 | 19571-5mg |
| 描述 | DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.1,2,3 The amount of oxidative stress is proportional to the amount of DMNQ applied and can alter diverse cellular parameters, including signal transduction, mitochondrial function, and gene expression.3,4,5 |
| 别名 | NSC 69355; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kaas, G.E.N.,Duddy, S.K., and Orrenius, S. Activation of hepatocyte protein kinase C by redox-cycling quinones. Biochemistry Journal 260(2), 499-507 (1989). 2.Gant, T.W.,Rao, D.N.,Mason, R.P., et al. Redox cycling and sulphydryl arylation; their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes. Chemico-Biological Interactions 65(2), 157-173 (1988). 3.Shi, M.M.,Kugelman, A.,Iwamoto, T., et al. Quinone-induced oxidative stress elevates glutathione and induces γ-glutamylcysteine synthetase activity in rat lung epithelial L2 cells. The Journal of Biological Chemisty 269(42), 26512-26517 (1994). 4.Klotz, L.O.,Hou, X., and Jacob, C. 1,4-Naphthoquinones: From oxidative damage to cellular and inter-cellular signaling. Molecules 19(9), 14902-14918 (2014). 5.Chacko, B.K.,Zhi, D.,Darley-Usmar, V.M., et al. The bioenergetic health index is a sensitive measure of oxidative stress in human monocytes. Reddox Biol. 8, 43-50 (2016). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 218.2 |
| 分子式 | C12H10O4 |
| CAS号 | 6956-96-3 |
| 稳定性 | ≥ 2 years |
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