| 货号 | 14482-50mg |
| 描述 | Gossypol is a racemic mixture of natural polyphenols isolated from parts of the cotton plant (genus Gossypium). It causes infertility in a variety of cotton pests and spermatogenesis arrest in humans.1 Gossypol also has antimalarial properties, preventing the growth of P. falciparum at low micromolar concentrations.2 It inhibits aldose reductase (Ki = 0.5 µM).3 Gossypol also acts as an anticancer agent, inhibiting cell growth in various cancer cell lines, in part by blocking the anti-apoptotic functions of Bcl-2 and Bcl-xL, again at low micromolar concentrations.4 |
| 别名 | BL 193;NSC 56817;NSC 624336;Pogosin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Coutinho, E.M. Gossypol: A contraceptive for men. Contraception 65(4), 259-263 (2002). 2.Royer, R.E.,Deck, L.M.,Campos, N.M., et al. Biologically active derivatives of gossypol: Synthesis and antimalarial activities of peri-acylated gossylic nitriles. Journal of Medicinal Chemistry 29(9), 1799-1801 (1986). 3.Deck, L.M.,Vander Jagt, D.L. and Royer, R.E. Gossypol and derivatives: A new class of aldose reductase inhibitors. Journal of Medicinal Chemistry 34(11), 3301-3305 (1991). 4.Yan, F.,Cao, X.X.,Jiang, H.X., et al. A novel water-soluble gossypol derivative increases chemotherapeutic sensitivity and promotes growth inhibition in colon cancer. Journal of Medicinal Chemistry 53(15), 5502-5510 (2010). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 518.6 |
| 分子式 | C30H30O8 |
| CAS号 | 303-45-7 |
| 稳定性 | ≥ 2 years |
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