| 货号 | 11350-1mg |
| 描述 | Thiolutin is a natural dithiol that reversibly inhibits bacterial and yeast RNA polymerases (IC50 = 3 μg/ml).1,2,3 Because of this, it can be used for the analysis of mRNA stability. Thiolutin also inhibits endothelial cell adhesion (IC50< 1 μM) and S180 tumor-induced angiogenesis in mice by inhibiting Hsp27 interactions with cytoskeletal elements.4,5 |
| 别名 | Acetopyrrothin;NSC 3927; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jimenez, A.,Tipper, D.J., and Davies, J. Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrobial Agents and Chemotherapy 3(6), 729-738 (1973). 2.Tipper, D.J. Inhibition of yeast ribonucleic acid polymerases by thiolutin. Journal of Bacteriology 116(1), 245-256 (1973). 3.Khachatourians, G.G., and Tipper, D.J. Inhibition of messenger ribonucleic acid synthesis in Escherichia coli by thiolutin. Journal of Bacteriology 119(3), 795-804 (1974). 4.Dai, S.,Jia, Y.,Wu, S.L., et al. Comprehensive characterization of heat shock protein 27 phosphorylation in human endothelial cells stimulated by the microbial dithiole thiolutin. Journal of Proteome Research 7(10), 4384-4395 (2008). 5.Jia, Y.,Wu, S.L.,Isenberg, J.S., et al. Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. Cell Stress and Chaperones 15, 165-181 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 228.3 |
| 分子式 | C8H8N2O2S2 |
| CAS号 | 87-11-6 |
| 稳定性 | ≥ 2 years |
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