| 货号 | 21758-1mg |
| 描述 | Curvularin is a natural fungal macrolactone that has cytotoxic activity against select cancer cell lines.1,2 It inhibits cytokine-induced expression of induced nitric oxide synthase (iNOS; IC50 = 9.5 µM) in vitro and reduces proinflammatory gene expression in a mouse model of rheumatoid arthritis.3,4 Curvularin also blocks TGF-β signaling in HepG2 and MDA-MB-231 cells.5 |
| 别名 | (-)-Curvularin;(S)-Curvularin;NSC 166071; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kumar, C.G.,Mongolla, P.,Sujitha, P., et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. Springerplus 2(1), 122 (2013). 2.Zhan, J.,Wijeratne, E.M.,Seliga, C.J., et al. A new anthraquinone and cytotoxic curvularins of a Penicillium sp. from the rhizosphere of Fallugia paradoxa of the Sonoran desert. J. Antibiot. (Tokyo) 57(5), 341-344 (2004). 3.Yao, Y.,Hausding, M.,Erkel, G., et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol. Pharmacol. 63(2), 383-391 (2003). 4.Schmidt, N.,Art, J.,Forsch, I., et al. The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis. J. Pharm. Exp. Ther. 343(1), 106-114 (2012). 5.Rudolph, K.,Serwe, A., and Erkel, G. Inhibition of TGF-β signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone. Cytokine 61(1), 285-296 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 292.3 |
| 分子式 | C16H20O5 |
| CAS号 | 10140-70-2 |
| 稳定性 | ≥ 2 years |
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