| 货号 | 21265-500ug |
| 描述 | MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both).1 It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively).1 MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum.2,3,4 |
| 别名 | Metalloproteinase-9/Metalloproteinase-13 Inhibitor I; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cheng, M.,De, B.,Pikul, S., et al. Design and synthesis of piperazine-based matrix metalloproteinase inhibitors. J. Med. Chem. 43(3), 369-380 (2000). 2.Prato, M.,Giribaldi, G.,Polimeni, M., et al. Phagocytosis of hemozoin enhances matrix metalloproteinase-9 activity and TNF-α production in human monocytes: Role of matrix metalloproteinases in the pathogenesis of falciparum malaria. J. Immunol. 175(10), 6436-6442 (2005). 3.Storz, P.,Döppler, H.,Copland, J.A., et al. FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases. Mol. Cell. Biol. 29(18), 4906-4917 (2009). 4.Swamydas, M.,Ricci, K.,Rego, S.L., et al. Mesenchymal stem cell-derived CCL-9 and CCL-5 promote mammary tumor cell invasion and the activation of matrix metalloproteinases. Cell Adh. Migr. 7(3), (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 495.6 |
| 分子式 | C25H25N3O6S |
| CAS号 | 204140-01-2 |
| 稳定性 | ≥ 2 years |
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