| 货号 | 19878-25mg |
| 描述 | Etretinate is a second-generation retinoid previously used systemically to manage psoriasis but withdrawn due to teratogenicity.1,2 Etretinate alters cAMP signaling, which may be defective in psoriasis.3,4 |
| 别名 | Ro 10-9359;Tegison; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hopkins, R.,Bird, H.A.,Jones, H., et al. A double-blind controlled trial of etretinate (Tigason) and ibuprofen in psoriatic arthritis. Ann. Rheum. Dis. 44(3), 189-193 (1985). 2.Turton, J.A.,Williars, G.B.,Haselden, J.N., et al. Comparative teratogenicity of nine retinoids in the rat. Int. J. Exp. Path. 73(5), 551-563 (1992). 3.Isuka, H.,Ohkuma, N., and Ohkawara, A. Effects of retinoids on the cyclic AMP system of pig skin epidermis. J. Invest. Dermatol. 85(4), 324-327 (1985). 4.Schopf, R.E.,Langendorf, Y.,Benz, R.E., et al. A highly decreased binding of cyclic adenosine monophosphate to protein kinase A in erythrocyte membranes is specific for active psoriasis. J. Invest. Dermatol. 119(1), 160-165 (2002). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 354.5 |
| 分子式 | C23H30O3 |
| CAS号 | 54350-48-0 |
| 稳定性 | ≥ 2 years |
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