Quercetagetin
货号：
18645-500ug 基本售价：
826.0 元 规格：
500 ug
产品信息
概述| 货号 | 18645-500ug |
| 描述 | The proto-oncogene serine/threonine-protein kinases, Pim-1 and Pim-2, are enzymes involved in cytokine signaling and participate in various signal transduction pathways, including cell growth, differentiation, and apoptosis. Their overexpression has been implicated in prostate cancer, some forms of leukemia, and lymphoma. Quercetagetin is a flavonol that inhibits Pim-1 with an IC50 value of 0.34 µM.1 It is selective for Pim-1, inhibiting Pim-2, PKA, RSK2, and JNK with IC50 values of 3.45, 21.2, 2.82, and 4.6 µM, respectively.1,2 Quercetagetin has been shown to inhibit Pim-1 activity in intact RWPE2 prostate cancer cells with an ED50 value of 5.5 µM, which led to significant growth inhibition.1 It can also inhibit the growth of additional prostate epithelial cell lines at a potency proportionate to their respective level of Pim-1 protein.1 |
| 别名 | 6-hydroxy Quercetin;NSC 115916; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Holder, S.,Zemskova, M.,Zhang, C., et al. Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Molecular Cancer Therapeutics 6(1), 163-172 (2007).
2.Baek, S.,Kang, N.J.,Popowicz, G.M., et al. Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. Journal of Molecular Biology 425(2), 411-423 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 318.2 |
| 分子式 | C15H10O8 |
| CAS号 | 90-18-6 |
| 稳定性 | ≥ 2 years |
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