| 货号 | 18632-50mg |
| 描述 | The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase mediates the rate-limiting step in cholesterol synthesis, converting HMG-CoA to mevalonate.1 3-hydroxy-3-Methylglutaric anhydride is a precursor that is used in the synthesis of HMG-CoA.2,3 It has also been used in the synthesis of 3-alkyl-3-hydroxyglutaric acids that act as inhibitors of HMG-CoA reductase.4 |
| 别名 | Dicrotalic anhydride;HMG anhydride; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yeganeh, B.,Wiechec, E.,Ande, S.R., et al. Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease. Pharmacology & Therapeutics 1143(1), 87-110 (2014). 2.Williamson, I.P., and Rodwell, V.W. Isolation and purification of 3-hydroxy-3-methylglutaryl-coenzyme A by ion-exchange chromatography. Journal of Lipid Research 22(1), 184-187 (1981). 3.Louw, A.I.,Bekersky, I., and Mosbach, E.H. Improved synthesis of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Journal of Lipid Research 10(6), 683-686 (1969). 4.Baran, J.S.,Laos, I.,Langford, D.D., et al. 3-Alkyl-3-hydroxyglutaric acids: A new class of hypocholesterolemic HMG CoA reductase inhibitors. Journal of Medicinal Chemistry 28(5), 597-601 (1985). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 144.1 |
| 分子式 | C6H8O4 |
| CAS号 | 34695-32-4 |
| 稳定性 | ≥ 2 years |
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