BI-847325
货号：
18301-1mg 基本售价：
826.0 元 规格：
1 mg
产品信息
概述| 货号 | 18301-1mg |
| 描述 | BI-847325 is a selective dual MEK/Aurora kinase inhibitor with IC50 values of 3, 25, 15, 25, and 4 nM for X. laevis Aurora B, human Aurora A and Aurora C, and human MEK1 and MEK2, respectively.1 It can inhibit the growth and survival of both treatment-naive and drug-resistant melanoma cell lines, decreasing the expression of MEK and Mcl-1 while increasing the expression of pro-apoptotic protein Bim.1 At 70 mg/kg, BI-847325 induces apoptosis in treatment-naive and drug-resistant xenografted melanoma in vivo.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Phadke, M.S.,Sini, P., and Smalley, K.S.M. The novel ATP-competitive MEK/aurora kinase inhibitor BI-847325 overcomes acquired BRAF inhibitor resistance through suppression of Mcl-1 and MEK expression. Molecular Cancer Therapeutics 14(6), 1354-1364 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 464.6 |
| 分子式 | C29H28N4O2 |
| CAS号 | 1207293-36-4 |
| 稳定性 | ≥ 2 years |
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