| 货号 | 16353-5mg |
| 描述 | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) is a deubiquitinating enzyme and thiol-dependent hydrolase.1,2,3,4 TCID is a tetrachloro indandione that acts as a potent inhibitor of UCH-L3 and demonstrates 125-fold selectivity over UCH-L1 (IC50s = 0.6 and 75 µM, respectively).5 |
| 别名 | UCH-L3 Inhibitor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mason, D.E.,Ek, J.,Peters, E.C., et al. Substrate profiling of deubiquitin hydrolases with a positional scanning library and mass spectrometry. Biochemistry 43(21), 6535-6544 (2004). 2.Setsuie, R.,Sakurai, M.,Sakaguchi, Y., et al. Ubiquitin dimers control the hydrolase activity of UCH-L3. Neurochemistry International 54(5-6), 314-321 (2009). 3.Wada, H.,Kito, K.,Caskey, L.S., et al. Cleavage of the C-terminus of NEDD8 by UCH-L3. Biochemical and Biophysical Research Communications 251(3), 668-692 (1998). 4.Iphöfer, A.,Kummer, A.,Nimtz, M., et al. Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes. ChemBioChem 13(10), 1416-1420 (2012). 5.Liu, Y.,Lashuel, H.A.,Choi, S., et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chemistry & Biology 10(9), 837-846 (2003). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 283.9 |
| 分子式 | C9H2Cl4O2 |
| CAS号 | 30675-13-9 |
| 稳定性 | ≥ 2 years |
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