| 货号 | 16182-1mg |
| 描述 | Mouse carboxylesterase 3 (Ces3, also named Ces1d) mediates triglyceride hydrolysis in white adipose tissue, liberating free fatty acids into circulation.1 Although important for basal lipolysis, Ces3 expression can be induced by xenobiotics.2,3 Ces3 activity is significantly elevated during adipocyte differentiation.4 WWL229 is a selective inhibitor of Ces3 (IC50 = 1.94 µM) that has no significant effect on other, related enzymes.4 By inhibiting the triglyceride hydrolase activity of Ces3, WWL229 promotes lipid storage in cultured adipocytes and prevents basal lipolysis.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Soni, K.G.,Lehner, R.,Metalnikov, P., et al. Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase. The Journal of Biological Chemisty 279(39), 40683-40689 (2004). 2.Wei, E.,Gao, W. and Lehner, R. Attenuation of adipocyte triacylglycerol hydrolase activity decreases basal fatty acid efflux. The Journal of Biological Chemisty 282(11), 8027-8035 (2007). 3.Furihata, T.,Hosokawa, M.,Koyano, N., et al. Identification of di-(2-ethylhexyl) phthalate-induced carboxylesterase 1 in C57BL/6 mouse liver microsomes: Purification, cDNA cloning, and baculovirus-mediated expression. Drug Metabolism and Disposition 32(10), 1170-1177 (2004). 4.Dominguez, E.,Galmozzi, A.,Chang, J.W., et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nature Chemical Biology 10(2), 113-121 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 322.4 |
| 分子式 | C16H22N2O5 |
| CAS号 | 1338575-28-2 |
| 稳定性 | ≥ 2 years |
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