Hedgehog Antagonist VIII
货号：
16097-500ug 基本售价：
826.0 元 规格：
500 ug
产品信息
概述| 货号 | 16097-500ug |
| 描述 | Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM.1 |
| 别名 | Hh Antagonist VIII; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Brunton, S.A.,Stibbard, J.H.,Rubin, L.L., et al. Potent inhibitors of the hedgehog signaling pathway. Journal of Medicinal Chemistry 51(5), 1108-1110 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 490.8 |
| 分子式 | C23H15ClF4N4O2 |
| CAS号 | 330796-24-2 |
| 稳定性 | ≥ 2 years |
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