| 货号 | 15870-10mg |
| 描述 | MreB is an actin-like protein expressed in bacteria.1 It determines the rod shape of cells and has critical roles in cell division, chromosome segregation, and cell polarity.2 MreB perturbing compound A22 is a benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly.3 It blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC = 3.1 µg/ml).4 It interferes with chromosome segregation in C. crescentus by preventing MreB binding to chromosomes.3InV. cholerae, A22 prevents the development of normal cell shape and alters nucleoid morphology.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Doi, M.,Wachi, M.,Ishino, F., et al. Determinations of the DNA sequence of the mreB gene and of the gene products of the mre region that function in formation of the rod shape of Escherichia coli cells. Journal of Bacteriology 170(10), 4619-4624 (1988). 2.Tan, Q.,Awano, N. and Inouye, M. YeeV is an Escherichia coli toxin that inhibits cell division by targeting the cytoskeleton proteins, FtsZ and MreB. Molecular Microbiology 79(1), 109-118 (2011). 3.Gitai, Z.,Dye, N.A.,Reisenauer, A., et al. MreB actin-mediated segregation of a specific region of a bacterial chromosome. Cell 120(3), 329-341 (2005). 4.Iwai, N.,Nagai, K. and Wachi, M. Novel S-benzylisothiourea compound that induces spherical cells in Escherichia coli probably by acting on a rod-shape-determining protein(s) other than penicillin-binding protein 2. Bioscience, Biotechnology, and Biochemistry 66(12), 2658-2662 (2002). 5.Srivastava, P. Changes in nucleoid morphology and origin localization upon inhibition or alteration of the actin homolog, MreB, of Vibrio cholerae. Journal of Bacteriology 189(20), 7450-7463 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 271.6 |
| 分子式 | C8H8Cl2N2S • HCl |
| CAS号 | 22816-60-0 |
| 稳定性 | ≥ 2 years |
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