Darunavir
货号：
15866-1mg 基本售价：
826.0 元 规格：
1 mg
产品信息
概述| 货号 | 15866-1mg |
| 描述 | Darunavir is a second generation protease inhibitor that targets the HIV-1 protease. It demonstrates extremely potent activity against the infectivity and replication of various strains of HIV-1, including several that are resistant to first generation protease inhibitors (IC50s = 3-30 nM).1 Darunavir has been reported to inhibit both cell-free diffusion and cell-to-cell spread of HIV-1 with IC50 values of 2.5 and 2.8 nM, respectively.2 |
| 别名 | Prezista®;TMC114; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Koh, Y.,Nakata, H.,Maeda, K., et al. Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrobial Agents and Chemotherapy 47(10), 3123-3129 (2003).
2.Titanji, B.K.,Aasa-Chapman, M.,Pillay, D., et al. Protease inhibitors effectively block cell-to-cell spread of HIV-1 between T cells. Retrovirology 10, 161 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 547.7 |
| 分子式 | C27H37N3O7S |
| CAS号 | 206361-99-1 |
| 稳定性 | ≥ 2 years |
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