| 货号 | 15421-5mg |
| 描述 | Nobiletin is a natural polymethoxylated flavonoid that can be isolated from citrus fruit peels. Like other polymethoxylated flavonoids, nobiletin is a potent antioxidant with good bioavailability.1,2 Presumably through antioxidant actions, nobiletin has anti-inflammatory effects that are relevant to a host of diseases, including cancer, arthritis, and neurodegeneration.2,3,4 Nobiletin directly inhibits the ATP-binding cassette proteins P-glycoprotein and breast cancer resistance protein (IC50 = 11.5 and 4.9 μM, respectively).5,6 |
| 别名 | NSC 76751;NSC 618903; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Walle, T. Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass? Semin.Cancer Biol. 17(5), 354-362 (2007). 2.Shen, C.L.,Smith, B.J.,Lo, D.F., et al. Dietary polyphenols and mechanisms of osteoarthritis. Journal of Nutritional Biochemistry 23(11), 1367-1377 (2012). 3.Meiyanto, E.,Hermawan, A. and Anindyajati. Natural products for cancer-targeted therapy: Citrus flavonoids as potent chemopreventive agents. Asian Pac.J.Cancer Prev. 13(2), 427-436 (2012). 4.Nakajima, A.,Aoyama, Y.,Nguyen, T.T.L., et al. Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse. Behavioural Brain Research 250, 351-360 (2013). 5.Pick, A.,Müller, H.,Mayer, R., et al. Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). Bioorganic & Medicinal Chemistry 19(6), 2090-2102 (2011). 6.Wang, E.j.,Lew, K.,Barecki, M., et al. Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chemical Research in Toxicology 14(12), 1596-1603 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 402.4 |
| 分子式 | C21H22O8 |
| CAS号 | 478-01-3 |
| 稳定性 | ≥ 2 years |
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