FCCP
货号：
15218-10mg 基本售价：
826.0 元 规格：
10 mg
产品信息
概述| 货号 | 15218-10mg |
| 描述 | FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.1,2 At 40 μM, FCCP induces complete depolymerization of microtubules by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the stability of microtubules by impairing the binding of microtubule-associated proteins.3 |
| 别名 | Trifluoromethoxy carbonylcyanide phenylhydrazone; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Parker, V.H. Uncouplers of rat-liver mitochondrial oxidative phosphorylation. Biochemistry Journal 97(3), 658-662 (1965).
2.Benz, R. and McLaughlin, S. The molecular mechanism of action of the proton ionophore FCCP (carbonylcyanide p-trifluoromethoxyphenylhydrazone). Biophysical Journal 41(3), 381-398 (1983).
3.Maro, B.,Marty, M.C. and Bornens, M. In vivo and in vitro effects of the mitochondrial uncoupler FCCP on microtubules. EMBO Journal 1(11), 1347-1352 (1982).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 254.2 |
| 分子式 | C10H5F3N4O |
| CAS号 | 370-86-5 |
| 稳定性 | ≥ 2 years |
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