| 货号 | 14948-500ug |
| 描述 | Calcein AM is a cell-permeable dye that, upon entering live cells, is cleaved by intracellular esterases, leaving membrane-impermeant calcein (Item No. 16221), a fluorescent indicator with absorption and emission maxima of 494 and 517 nm, respectively. It can be used as an indicator of cell viability, cell-cell communication, cytotoxicity, or changes in intracellular calcium, fluoride, iron, or mercury.1,2 As calcein is a substrate for multidrug resistance-associated protein 1 (MRP1) and multidrug resistance protein 3 (MDR3, P-glycoprotein 3), calcein AM is used to study these proteins and their regulation.3,4,5 |
| 别名 | Calcein Acetoxymethyl ester;NSC 689290; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hynes, J.,Floyd, S.,Soini, A.E., et al. Fluorescence-based cell viability screening assays using water-soluble oxygen probes. Journal of Biomolecular Screening 8, 264-272 (2003). 2.Sabnis, R.W. Handbook of biological dyes and stains: Synthesis and industrial applications. (2010). 3.Polli, J.W.,Wring, S.A.,Humphreys, J.E., et al. Rational use of in vitro P-glycoprotein assays in drug discovery. Journal of Pharmacology and Experimental Therapeutics 299(2), 620-628 (2001). 4.Tiberghien, F. and Loor, F. Ranking of P-glycoprotein substates and inhibitors by a calcein-AM fluorometry screening assay. Anti-Cancer Drugs 7(5), 568-578 (1996). 5.Szakács, G.,Jakab, K.,Antal, F., et al. Diagnostics of multidrug resistance in cancer. Pathol.Oncol.Res. 4(4), 251-257 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 计算分子量 | 994.9 |
| 分子式 | C46H46N2O23 |
| CAS号 | 148504-34-1 |
| 稳定性 | ≥ 6 months |
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