| 货号 | 14597-10mg |
| 描述 | Honokiol is a natural product derived from parts of the plant M. grandiflora used in Oriental herbal medicine. It is a lignan that produces diverse therapeutic effects, including acting as an anxiolytic in mice.1 Honokiol also inhibits nuclear factor-κB and phosphoinositide 3-kinase/Akt signaling, preventing inflammation, and interferes with angiogenesis while preventing tumor growth in vivo.2,3,4,5 It also scavenges superoxide and peroxyl radicals.6 |
| 别名 | NSC 293100; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Maruyama, Y.,Kuribara, H.,Morita, M., et al. Identification of magnolol and honokiol as anxiolytic agents in extracts of Saiboku-to, an oriental herbal medicine. Journal of Natural Products 61(1), 135-138 (1998). 2.Bai, X.,Cerimele, F.,Ushio-Fukai, M., et al. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. The Journal of Biological Chemisty 278(37), 35501-35507 (2003). 3.Ahn, K.S.,Sethi, G.,Shishodia, S., et al. Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway. Molecular Cancer Research 4(9), 621-633 (2006). 4.Singh, T. and Katiyar, S.K. Honokiol inhibits non-small cell lung cancer cell migration by targeting PGE2-mediated activation of β-catenin signaling. PLoS One 8(4), (2013). 5.Kim, B.H. and Cho, J.Y. Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta.Pharmacol.Sin. 29(1), 113-122 (2008). 6.Dikalov, S.,Losik, T. and Arbiser, J.L. Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochemical Pharmacology 76(5), 589-596 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 266.3 |
| 分子式 | C18H18O2 |
| CAS号 | 35354-74-6 |
| 稳定性 | ≥ 2 years |
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