JNJ-1661010
货号：
14497-5mg 基本售价：
826.0 元 规格：
5 mg
产品信息
概述| 货号 | 14497-5mg |
| 描述 | Fatty acid amide hydrolase (FAAH) degrades N-acyl ethanolamines, including the endocannabinoid arachidonoyl ethanolamide (AEA). JNJ-1661010 is a selective inhibitor of FAAH (IC50s = 34 and 33 nM in rat and human, respectively) that is able to cross the blood-brain barrier.1 At 20 mg/kg, JNJ-1661010 has been shown to elevate levels of AEA in rat brain.1 This compound has been used to examine the contribution of endocannabinoid signaling in experimental fibrosis.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Keith, J.M.,Apodaca, R.,Xiao, W., et al. Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters 18(17), 4838-4843 (2008).
2.Palumbo-Zerr, K.,Horn, A.,Distler, A., et al. Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1. Annals of the Rheumatic Diseases 71, 2051-2054 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 365.5 |
| 分子式 | C19H19N5OS |
| CAS号 | 681136-29-8 |
| 稳定性 | ≥ 2 years |
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