| 货号 | 15599-5mg |
| 描述 | SNC 80 is a selective non-peptide agonist of the δ-opioid receptor (Ki = 0.18 nM, IC50 = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor.1,2,3 It effectively activates µ/δ receptor heteromers (EC50 = 52.8 nM) but not κ/δ or μ/κ heteromers.4 SNC 80 has antinociceptive as well as pro-convulsant effects in vivo.1,2,5 |
| 别名 | NIH 10815; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bilsky, E.J.,Calderon, S.N.,Wang, T., et al. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. Journal of Pharmacology and Experimental Therapeutics 273(1), 359-366 (1995). 2.Calderon, S.N.,Rothman, R.B.,Porreca, F., et al. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A highly selective, nonpeptide δ opioid receptor agonist. Journal of Medicinal Chemistry 37(14), 2125-2128 (1994). 3.Knapp, R.J.,Santoro, G.,De Leon, I.A., et al. Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. Journal of Pharmacology and Experimental Therapeutics 277(3), 1284-1291 (1996). 4.Metcalf, M.D.,Yekkirala, A.S.,Powers, M.D., et al. The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors. ACS Chem.Neurosci. 3(7), 505-509 (2012). 5.Danielsson, I.,Gasior, M.,Stevenson, G.W., et al. Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys. Pharmacology, Biochemistry, and Behavior 85(2), 428-434 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 449.6 |
| 分子式 | C28H39N3O2 |
| CAS号 | 156727-74-1 |
| 稳定性 | ≥ 2 years |
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