S14161
货号：
14187-1mg 基本售价：
825.0 元 规格：
1 mg
产品信息
概述| 货号 | 14187-1mg |
| 描述 | D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM).1 S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s< 10 μM) but is less toxic to normal hematopoietic cells (IC20 > 25 μM).1 In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mao, X.,Cao, B.,Wood, T.E., et al. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood 117(6), 1986-1997 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 315.3 |
| 分子式 | C17H14FNO4 |
| CAS号 | 883046-50-2 |
| 稳定性 | ≥ 2 years |
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