2-deoxy-D-Glucose-6-phosphate (sodium salt)
货号：
17149-10mg 基本售价：
812.0 元 规格：
10 mg
产品信息
概述| 货号 | 17149-10mg |
| 描述 | 2-deoxy-D-Glucose (2-DG, Item No. 14325) is a synthetic analog of glucose used in cell metabolism and cancer research.1 2-deoxy-D-Glucose-6-phosphate (2-DG6P) is a derivative of 2-DG. It is produced in mammalian cells by the action of hexokinase on 2-DG. The accumulation of 2-DG6P in cells can inhibit glycolysis, leading to cell death.2 However, the uptake of 2-DG by cells can be monitored in assays by the accumulation of 2-DG6P, which can be oxidized in vitro by glucose 6-phosphate dehydrogenase and reduce NADP+. In bacteria and yeast, 2-DG6P is metabolized to 2-DG by 2-DG6P phosphatase. |
| 别名 | 2-Deoxyglucose-6-phosphate;2-DG6P; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kang, H.T. and Hwang, E.S. 2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sciences 78(12), 1392-1399 (2006).
2.Urakami, K.,Zangiacomi, V.,Yamaguchi, K., et al. Impact of 2-deoxy-D-glucose on the target metabolite profile of a human endometrial cancer cell line. Biomed.Res. 34(5), 221-229 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 266.1 |
| 分子式 | C6H12O8P • Na |
| 稳定性 | ≥ 2 years |
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