CBFβ Inhibitor
货号：
16771-5mg 基本售价：
812.0 元 规格：
5 mg
产品信息
概述| 货号 | 16771-5mg |
| 描述 | Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ.1 CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias.1,2 CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 µM).3 It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.3 |
| 别名 | Core Binding Factor-β Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Link, K.A.,Chou, F.S. and Mulloy, J.C. Core binding factor at the crossroads: Determining the fate of the HSC. Journal of Cellular Physiology 222(1), 50-56 (2010).
2.Swiers, G.,de Bruijn, N. and Speck, N.A. Hematopoietic stem cell emergence in the conceptus and the role of Runx1. International Journal of Developmental Biology 54(6-7), 1151-1163 (2010).
3.Gorczynski, M.J.,Grembecka, J.,Zhou, Y., et al. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFβ. Chemistry & Biology 14(10), 1186-1197 (2007).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 234.3 |
| 分子式 | C12H14N2OS |
| CAS号 | 493028-20-9 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
